SPONSOR EVENTS
During the lunch period on Tuesday and Wednesday you have the opportunity to join a presentation hosted by one of our Platinum Sponsors. Advanced sign-up is required to attend. You can update your registration record to attend these presentations if you did not make a selection at the time of registration. Follow the instructions below to update your record.
- Click the Sign-up Now! button below.
- Select "Sign in with your existing account" and enter your email address and password to log in.
- Click any blue "Edit" button to make your selections.
- Click "Next" until you reach the final page and click "Submit".
Agilent Technologies
Tuesday, June 20
12:20 - 1:20 p.m.
Metabolon
Tuesday, June 20
12:20 - 1:20 p.m.
Thermo Fisher Scientific
Wednesday, June 21
12:20 - 1:20 p.m.
Thermo Fisher Scientific Privacy Policy
To learn more about Thermo Fisher Scientific's presentation, click here.
Bruker
Wednesday, June 21
12:20 - 1:20 p.m.
Vendor Presentations
(Presented by Platinum and Gold sponsors)
Date: Tuesday, June 20
Time: 3:30 p.m. – 5:15 p.m.
Location: Fallsview
Platinum Presenter Group: 3:30 p.m. – 4:25 p.m.
Thermo Fisher Scientific
Susan S. Bird, Sr. Manager, Metabolomics and Lipidomics Team Lead, United States
Simultaneous Quantitation and Discovery (SQUAD) Metabolomics: Orbitrap based methods to empower your research
Simultaneous quantitation and discovery (SQUAD) metabolomics provides confident identification and/or accurate quantitation of preselected metabolites, without compromising the untargeted analysis. When available, analyzing authentic standards of target compounds, provides absolute quantitation, standardizing response across instrument platforms and laboratories providing additional quality control and assurance to the study. The simultaneous acquisition of HRAM full scan data, future proofs the discovery of metabolites through data retro mining as new targets of interest are discovered. In our vendor session we will focus on introducing SQUAD analysis to the community as applied to our orbitrap based mass spectrometers with a focus on our new Orbitrap Astral MS. In a single analytical injection, the SQUAD analysis solution provides confident identification and quantification of targeted metabolites, while also acquiring untargeted profiling data used for differential analysis, unknown annotation, and biomarker discovery. ThermoFisher Scientific is committed to advancing the field of metabolomics through intelligence driven data acquisition, streamlined software processing strategies and key hardware innovations that keep at pace and push beyond the current analytical demands of the field.
SCIEX
David Colquhoun, Market Development Manager, USA
ZenoTOF 7600: Technology Introduction
With the introduction of the SCIEX ZenoTOF 7600 system, scientists can now achieve quantitative results at high speeds with high mass accuracy. The core innovation on the ZenoTOF7600 system is the Zeno trap that when activated, provides significant improvements in duty cycle due to the optimization of ion transmission from the collision cell into the accelerator. This duty cycle improvement provides a substantial increase in MS/MS sensitivity and thus enables targeted and untargeted high resolution workflows. This presentation will highlight the technical features of the ZenoTOF 7600 for metabolomics research.
Bruker
Matthew R. Lewis PhD, FRSC, Director of Metabolomics Applications, United States
Unlock the Power of NMR and MS in Metabolomics: A Comprehensive Approach
Discover how NMR, LC-MS, and GC-MS technologies by Bruker drive groundbreaking metabolomics and phenomics discoveries.
Mass Spectrometry Solutions:
Bruker is taking strides to standardize the field of metabolomics and lipidomics by providing a means to monitor data accuracy and precision as it’s being acquired. Today’s talk will give you a preview of RealTime QC and how Bruker is addressing current research requirements in high quality, standardized data.
Speed and sensitivity are also at the forefront of our technology, with PASEF enabling researchers to acquire more meaningful fragmentation data using rapid gradients at acquisitions rates >100 Hz. In addition, with trapped ion mobility acquiring CCS measurements, we harness this orthogonal physical property as a key tool in annotation.
Automated NMR Solutions:
NMR-based metabolomics provides insights into metabolic phenotypes enabling personalized medicine and nutrition applications for optimized health.
New solutions for Bruker’s standardized and automated Avance IVDr NMR platform:
- PhenoRisk PACS RuO* is a single 20-minute blood test providing insights into Post COVID Conditions research, potentially detecting clinically well-characterized risk markers of cardiovascular disease, diabetes, kidney dysfunction and inflammation.
- MetaboTracker is a personalized urinary dietary advice test giving access to metabolic insights to improve diet for a better health. The multiparametric urinary analysis check adherence to WHO standards and track progress over time by measuring accurately the impact of the individual diet on the individual health goals.
Agilent Technologies
Dan Cuthbertson, Global Cell Biology & Disease Research Segment Manager, USA
Agilent Solutions for Metabolomics Research
Innovative metabolomics solutions from Agilent provide a powerful portfolio of instruments and informatics tools. A common software platform combines the results from multiple analytical techniques, helping answer challenging biological questions faster. Agilent collaborates with leading metabolomics scientists to develop next-generation solutions and workflows to accelerate your metabolomics research. Today we will provide a brief overview of Agilent’s solutions for metabolomics researchers.
Metabolon
Dr. Annie Evans, Sr. Director, Head of Core Research, United States
Small Molecules, Big Insights - Delivering on the full potential of Metabolomics
Metabolon is a full untargeted and targeted metabolomics service provider with full accreditation from the International Organization for Standardization (ISO) and the College of America Pathologists (CAP). Metabolon earned these accreditations by performing extensive analytical, biological, and clinical validations on our methods and by demonstrating a commitment to continued monitoring, process improvement, and client focus. Metabolon’s dedication to providing the highest quality data together with collaborative support on understanding the data for the investigators we work with means faster generation of insights and actionable outcomes. In this presentation, we will highlight the validations performed and the quality systems at the core of our methodology.
Gold Presenter Group: 4:25 p.m. – 5:15 p.m.
LECO Corporation
John Hayes, Separation Science Product Manager, USA
From Derivatization to Data Processing - Developing the Complete GC Metabolomics Solution
The metabolome presents an immense analytical challenge: How does one collect and process the thousands of annotations from a single sample, from acids to amides, sugars to sterols, and so much more? Mass spectrometry techniques have become the standard, but inherent limitations of ionization sources and upstream chromatographs necessitate an array of instruments for labs seeking complete chemical insights. In this presentation, learn how LECO's innovative, start-to-finish GCMS metabolomics solution can help labs add to the richness of their metabolomics data.
biocrates life sciences ag
Alice Limonciel, Senior scientist | Scientific storytelling, Austria
Quantitative Metabolomics Database (QMDB): Get access to reference ranges for 630 metabolites
Quantitative metabolomics reference data is scarce. Reliable reference data is important to enable clinical decision-making processes, facilitate the evaluation of epidemiological cohort studies, and validate metabolic biomarker signatures. The Quantitative Metabolomics Database (QMDB) provides quantitative EDTA-plasma metabolite concentration ranges for healthy human adults derived from analyses using the biocrates standardized MxP® Quant 500 kit. Harnessing the reproducibility of biocrates technology across multiple centers, the samples were obtained from > 2,500 healthy adults of all ages, using controlled epidemiological study data provided by several collaborating scientific institutes and universities. Using filtering based on age, sex, BMI and other factors, the QMDB can be queried to generate the reference ranges that best fit a given project. We will present examples of applications of the QMDB to study the evolution of the metabolome across the adult lifespan, and in a case/control study of inflammatory bowel disease (IBD), with a particular focus to the interpretability of the results enabled by quantitative metabolomics.
Owlstone Medical
Dr Elizabeth Crone, Head of Business Development - Research Products and Services, United Kingdom
The ATLAS Project: Mapping Volatile Metabolites in Breath for Non-Invasive Biomarker Discovery
There are hundreds of volatile metabolites exhaled on breath and it presents a rich source of information for development of non-invasive biomarkers. However, external libraries to support identification of molecules following global analysis are not sufficient for high confidence identification, and breath sampling technologies can make it difficult to work out which molecules are actually from human breath and which are present in the ambient air. In this talk, we will outline the ATLAS project which aims to map the human breath volatile metabolome and provide a library to enable identification of clinically translatable biomarkers.
Cambridge Isotope Labs
Andrew Percy, PhD, Senior Applications Scientist, USA
Standard Isotopic Tools for QC and Quantification in MS Metabolomics
The global and targeted measurement of metabolites continues to be an area of growing focus in analytical chemistry and biomedicine. Drivers for metabolomics research include efforts to better understand the mechanisms of disease pathogenesis and to accelerate biomarker screening toward improved precision medicine. Such works are facilitated by improvements in experimental methodologies, instrumentation technologies, and bioinformatic tools. Further aiding metabolomic studies are precisely formulated, stable isotope-labeled mixtures. This presentation will highlight CIL’s latest mixes (e.g., bile acids) and demonstrate how they can be integrated into MS metabolomic workflows toward improved process benchmarking and sample stratification in research applications.
Miltenyi Biotec
Megan Ciarlo, Technology and Applications Specialist, United States of America
Realize authentic metabolomics data through gentle microfluidics cell sorting
In recent years, it has become widely accepted that traditional cell-sorting approaches — such as droplet or jet-in-air methods — induce changes in the cellular metabolome, moving cells further away from their base physiological state. Referred to as sorter induced cell stress (SICS), this phenomenon has been well documented in literature using common metabolomic assays.
Although it been shown that using complete media as sheath fluid (CMAS) can mitigate these effects to some extent, this is not a feasible solution in most labs.2 Therefore, it is necessary to look to gentler cell-sorting methods in order to reduce or eliminate these effects and subsequently obtain high-quality metabolomic data that is more representative of a cell’s base physiological state.
The MACSQuant® Tyto® Cell Sorter facilitates gentle high-speed multiparameter flow sorting using a microchip- and microfluidics-based technology. Cell sorting with this fully closed system occurs at a low pressure, under mild shear forces, and without decompression or charge. This approachable, mild, and closed cell-sorting method is suitable for a broad range of samples and cell types.
METABOLOMICS SOCIETY | metabolomicssociety.org